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62.Vater, A., and S. Klussmann. 2003. Toward third-generation aptamers: Spiegelmers and their therapeutic prospects. Current Opinion in Drug Discovery & Development. 6(2):253-261.
61.Chamberlin, S. I., and K. M. Weeks. 2003. Differential helix stabilities and sites pre-organized for tertiary interactions revealed by monitoring local nucleotide flexibility in the bI5 group I intron RNA. Biochemistry. 42(4):901-909.
60.Krider, E. S., J. E. Miller, and T. J. Meade. 2002. 2 '-modified nucleosides for site-specific labeling of oligonucleotides. Bioconjugate Chemistry. 13(1):155-162.
59.Chamberlin, S. I., E. J. Merino, and K. M. Weeks. 2002. Catalysis of amide synthesis by RNA phosphodiester and hydroxyl groups. Proceedings of the National Academy of Sciences of the United States of America. 99(23):14688-14693.
58.John, D. M., and K. M. Weeks. 2002. Chemical interrogation of mismatches in DNA-DNA and DNA-RNA duplexes under nonstringent conditions by selective 2 '-amine acylation. Biochemistry. 41(21):6866-6874.
57.Shan, S. O., and D. Herschlag. 2002. Dissection of a metal-ion-mediated conformational change in Tetrahlymena ribozyme catalysis. Rna-a Publication of the Rna Society. 8(7):861-872.
56.Klostermeier, D., and D. P. Millar. 2001. Time-resolved fluorescence resonance energy transfer: A versatile tool for the analysis of nucleic acids. Biopolymers. 61(3):159-179.
55.Gallo, M., E. Monteagudo, D. O. Cicero, H. N. Torres, and A. M. Iribarren. 2001. 2 '-C-methyluridine phosphoramidite: a new building block for the preparation of RNA analogues carrying the 2 '-hydroxyl group. Tetrahedron. 57(27):5707-5713.
54.Teramoto, N., H. Ichinari, N. Kawazoe, Y. Imanishi, and Y. Ito. 2001. Peroxidase activity of in vitro-selected 2 '-amino RNAs. Biotechnology and Bioengineering. 75(4):463-468.
53.Kryatova, O. P., W. H. Connors, C. F. Bleczinski, A. A. Mokhir, and C. Richert. 2001. A 2 '-acylamido cap that increases the stability of oligonucleotide duplexes. Organic Letters. 3(7):987-990.
52.Williams, D. J., J. L. Boots, and K. B. Hall. 2001. Thermodynamics of 2 '-ribose substitutions in UUCG tetraloops. Rna-a Publication of the Rna Society. 7(1):44-53.
51.Wojczewski, C., and J. W. Engels. 2000. Synthesis of 3 '-S-(2-aminoethylthio)-3 '-deoxythymidine-5 '- triphosphates. Synthesis-Stuttgart(1):149-153.
50.Chamberlin, S. I., and K. M. Weeks. 2000. Mapping local nucleotide flexibility by selective acylation of 2 '-amine substituted RNA. Journal of the American Chemical Society. 122(2):216-224.
49.Beaudry, A., J. DeFoe, S. Zinnen, A. Burgin, and L. Beigelman. 2000. In vitro selection of a novel nuclease-resistant RNA phosphodiesterase. Chemistry & Biology. 7(5):323-334.
48.Gordon, P. M., E. J. Sontheimer, and J. A. Piccirilli. 2000. Kinetic characterization of the second step of group II intron splicing: Role of metal ions and the cleavage site 2 '-OH in catalysis. Biochemistry. 39(42):12939-12952.
47.Yoshida, A., S. Shan, D. Herschlag, and J. A. Piccirilli. 2000. The role of the cleavage site 2 '-hydroxyl in the Tetrahymena group I ribozyme reaction. Chemistry & Biology. 7(2):85-96.
46.John, D. M., and K. M. Weeks. 2000. Tagging DNA mismatches by selective 2 '-amine acylation. Chemistry & Biology. 7(6):405-410.
18.Shan, S. O., G. J. Narlikar, and D. Herschlag. 1999. Protonated 2 '-aminoguanosine as a probe of the electrostatic environment of the active site of the Tetrahymena group I ribozyme. Biochemistry. 38(34):10976-10988.
45.Venkateswarlu, D., K. E. Lind, V. Mohan, M. Manoharan, and D. M. Ferguson. 1999. Structural properties of DNA : RNA duplexes containing 2 '-O- methyl and 2 '-S-methyl substitutions: a molecular dynamics investigation. Nucleic Acids Research. 27(10):2189-2195.
44.Wojczewski, C., K. Stolze, and J. W. Engels. 1999. Fluorescent oligonucleotides - Versatile tools as probes and primers for DNA and RNA analysis. Synlett(10):1667-1678.
43.Sigurdsson, S. T. 1999. Thiol-containing RNA for the study of structure and function of ribozymes. Methods-a Companion to Methods in Enzymology. 18(1):71-77.
42.Yamana, K., T. Mitsui, and H. Nakano. 1999. Synthesis and properties of oligonucleotide duplexes containing donor and acceptor fluorophores at 2 '-positions. Tetrahedron. 55(30):9143-9150.
41.Qin, P. Z. F., and A. M. Pyle. 1999. Site-specific labeling of RNA with fluorophores and other structural probes. Methods-a Companion to Methods in Enzymology. 18(1):60-70.
40.Thibaudeau, C., N. Nishizono, Y. Sumita, A. Matsuda, and J. Chattopadhyaya. 1999. Determination of the group electronegativity of CF3 group in 3 '-O-CF3-thymidine by H-1-NMR. Nucleosides & Nucleotides. 18(4-5):1035-1053.
39.Zhou, D. M., and K. Taira. 1998. The hydrolysis of RNA: From theoretical calculations to the hammerhead ribozyme-mediated cleavage of RNA. Chemical Reviews. 98(3):991-1026.
38.Greiner, B., and W. Pfleiderer. 1998. Nucleotides - Part LVII - Synthesis of phosphoramidite building blocks of 2 '-amino-2 '-deoxyribonucleosides: New compounds for oligonucleotide synthesis. Helvetica Chimica Acta. 81(8):1528-1544.
37.Nishizono, N., Y. Sumita, Y. Ueno, and A. Matsuda. 1998. Effects of 2 '-O-(trifluoromethyl)adenosine on oligodeoxynucleotide hybridization and nuclease stability. Nucleic Acids Research. 26(22):5067-5072.
36.Ogawa, A., M. Tanaka, T. Sasaki, and A. Matsuda. 1998. Nucleosides and nucleotides. 180. Synthesis and antitumor activity of nucleosides that have a hydroxylamino group instead of a hydroxyl group at the 2 '- or 3 '-position of the sugar moiety. Journal of Medicinal Chemistry. 41(25):5094-5107.
25.Jenne, A., and M. Famulok. 1998. A novel ribozyme with ester transferase activity. Chemistry & Biology. 5(1):23-34.
34.Ruckman, J., L. S. Green, J. Beeson, S. Waugh, W. L. Gillette, D. D. Henninger, L. Claesson-Welsh, and N. Janjic. 1998. 2 '-fluoropyrimidine RNA-based aptamers to the 165-amino acid form of vascular endothelial growth factor (VEGF(165)) - Inhibition of receptor binding and VEGF-induced vascular permeability through interactions requiring the exon 7-encoded domain. Journal of Biological Chemistry. 273(32):20556-20567.
33.Antsypovich, S. I., and T. S. Oretskaya. 1998. Double-stranded cross-linked nucleic acids. Synthesis and applications in the molecular biology. Uspekhi Khimii. 67(3):274-293.
32.Narlikar, G. J., M. Khosla, N. Usman, and D. Herschlag. 1997. Quantitating tertiary binding energies of 2' OH groups on the P1 duplex of the Tetrahymena ribozyme: Intrinsic binding energy in an RNA enzyme. Biochemistry. 36(9):2465-2477.
31.Owczarzy, R., P. M. Vallone, F. J. Gallo, T. M. Paner, M. J. Lane, and A. S. Benight. 1997. Predicting sequence-dependent melting stability of short duplex DNA oligomers. Biopolymers. 44(3):217-239.
30.Pagratis, N. C., C. Bell, Y. F. Chang, S. Jennings, T. Fitzwater, D. Jellinek, and C. Dang. 1997. Potent 2'-amino-, and 2'-fluoro-2'-deoxyribonucleotide RNA inhibitors of keratinocyte growth factor. Nature Biotechnology. 15(1):68-73.
29.Randolph, J. B., and A. S. Waggoner. 1997. Stability, specificity and fluorescence brightness of multiply- labeled fluorescent DNA probes. Nucleic Acids Research. 25(14):2923-2929.
28.Schwille, P., F. J. MeyerAlmes, and R. Rigler. 1997. Dual-color fluorescence cross-correlation spectroscopy for multicomponent diffusional analysis in solution. Biophysical Journal. 72(4):1878-1886.
27.Freier, S. M., and K. H. Altmann. 1997. The ups and downs of nucleic acid duplex stability: structure- stability studies on chemically-modified DNA:RNA duplexes. Nucleic Acids Research. 25(22):4429-4443.
26.Kujau, M. J., A. Siebert, and S. Wolfl. 1997. Design of leader sequences that improve the efficiency of the enzymatic synthesis of 2 '-amino-pyrimidine RNA for in vitro selection. Journal of Biochemical and Biophysical Methods. 35(3):141-151.
25.Patel, B. K., J. B. Thomson, V. Jimenez, K. Eckart, and F. Eckstein. 1997. Properties of some diuridine phosphate analogues. Nucleosides & Nucleotides. 16(7-9):1443-1446.
24.BarberPeoch, I., M. Manoharan, and P. D. Cook. 1997. Solid phase conjugation chemistry: Use of alloc as a protecting group for 2'-aminolinker containing oligonucleotides. Nucleosides & Nucleotides. 16(7-9):1407-1410.
41.Meade, T. J. 1996. Electron transfer reactions through the DNA double helix, p. 453-478, Metal Ions in Biological Systems, Vol 32, vol. 32.
23.McGee, D. P. C., A. VaughnSettle, C. Vargeese, and Y. S. Zhai. 1996. 2'-Amino-2'-deoxyuridine via an intramolecular cyclization of a trichloroacetimidtate. Journal of Organic Chemistry. 61(2):781-785.
22.Sigurdsson, S. T., and F. Eckstein. 1996. Site specific labelling of sugar residues in oligoribonucleotides: Reactions of aliphatic isocyanates with 2' amino groups. Nucleic Acids Research. 24(16):3129-3133.
21.Fukui, K., M. Morimoto, H. Segawa, K. Tanaka, and T. Shimidzu. 1996. Synthesis and properties of an oligonucleotide modified with an acridine derivative at the artificial abasic site. Bioconjugate Chemistry. 7(3):349-355.
20.Thomson, J. B., B. K. Patel, V. Jimenez, K. Eckart, and F. Eckstein. 1996. Synthesis and properties of diuridine phosphate analogues containing thio and amino modifications. Journal of Organic Chemistry. 61(18):6273-6281.
19.Schmidt, S., D. J. Earnshaw, S. T. Sigurdsson, F. Eckstein, and M. J. Gait. 1996. Probing the tertiary structure of the hairpin ribozyme by chemical crosslinking. Collection of Czechoslovak Chemical Communications. 61:S276-S279.
18.Meade, T. J., and J. F. Kayyem. 1995. Electron-Transfer Through Dna - Site-Specific Modification of Duplex Dna With Ruthenium Donors and Accepters. Angewandte Chemie-International Edition in English. 34(3):352-354.
17.Green, L. S., D. Jellinek, C. Bell, L. A. Beebe, B. D. Feistner, S. C. Gill, F. M. Jucker, and N. Janjic. 1995. Nuclease-Resistant Nucleic-Acid Ligands to Vascular- Permeability Factor Vascular Endothelial Growth-Factor. Chemistry & Biology. 2(10):683-695.
16.Iwai, S., S. Kataoka, M. Wakasa, E. Ohtsuka, and H. Nakamura. 1995. Recognition of 2'-Hydroxyl Groups By Escherichia-Coli Ribonuclease Hi. Febs Letters. 368(2):315-320.
15.Li, H., K. Porter, F. Q. Huang, and B. R. Shaw. 1995. Boron-Containing Oligodeoxyribonucleotide 14mer Duplexes - Enzymatic-Synthesis and Melting Studies. Nucleic Acids Research. 23(21):4495-4501.
14.Pilch, D. S., G. E. Plum, and K. J. Breslauer. 1995. The Thermodynamics of Dna Structures That Contain Lesions or Guanine Tetrads. Current Opinion in Structural Biology. 5(3):334-342.
13.Hendrix, C., B. Devreese, J. Rozenski, A. Vanaerschot, A. Debruyn, J. Vanbeeumen, and P. Herdewijn. 1995. Incorporation of 2'-Amido-Nucleosides in Oligodeoxynucleotides and Oligoribonucleotides As a Model For 2'-Linked Conjugates. Nucleic Acids Research. 23(1):51-57.
12.Ecker, D. J., and S. T. Crooke. 1995. Combinatorial Drug Discovery - Which Methods Will Produce the Greatest Value. Bio-Technology. 13(4):351-360.
11.Jellinek, D., L. S. Green, C. Bell, C. K. Lynott, N. Gill, C. Vargeese, G. Kirschenheuter, D. P. C. McGee, P. Abesinghe, W. A. Pieken, R. Shapiro, D. B. Rifkin, D. Moscatelli, and N. Janjic. 1995. Potent 2'-Amino-2'-Deoxypyrimidine Rna Inhibitors of Basic Fibroblast Growth-Factor. Biochemistry. 34(36):11363-11372.
10.Eaton, B. E., and W. A. Pieken. 1995. Ribonucleosides and Rna. Annual Review of Biochemistry. 64:837-863.
9.Sigurdsson, S. T., T. Tuschl, and F. Eckstein. 1995. Probing Rna Tertiary Structure - Interhelical Cross-Linking of the Hammerhead Ribozyme. Rna-a Publication of the Rna Society. 1(6):575-583.
8.Johnson, R., C. B. Reese, and Z. Peizhuo. 1995. Lability of Glycosidic Linkages of 2'-Thio-Ribonucleosides. Tetrahedron. 51(17):5093-5098.
7.Manoharan, M., K. L. Tivel, L. K. Andrade, and P. D. Cook. 1995. 2'-O-Pyrimidine and 3'-O-Pyrimidine Aminotether-Containing Oligonucleotides - Synthesis and Conjugation Chemistry. Tetrahedron Letters. 36(21):3647-3650.
6.Aurup, H., T. Tuschl, F. Benseler, J. Ludwig, and F. Eckstein. 1994. Oligonucleotide Duplexes Containing 2'-Amino-2'Deoxycytidines - Thermal-Stability and Chemical-Reactivity (Vol 22, Pg 20, 1994). Nucleic Acids Research. 22(4):701-701.
5.Tuschl, T., C. Gohlke, T. M. Jovin, E. Westhof, and F. Eckstein. 1994. 3-Dimensional Model For the Hammerhead Ribozyme Based On Fluorescence Measurements. Science. 266(5186):785-789.
4.Aurup, H., A. Siebert, F. Benseler, D. Williams, and F. Eckstein. 1994. Translation of 2'-Modified Messenger-Rna in-Vitro and in-Vivo. Nucleic Acids Research. 22(23):4963-4968.
3.Uchiyama, Y., Y. Miura, H. Inoue, E. Ohtsuka, Y. Ueno, M. Ikehara, and S. Iwai. 1994. Studies of the Interactions Between Escherichia-Coli Ribonuclease Hi and Its Substrate. Journal of Molecular Biology. 243(4):782-791.
2.Griffey, R. H., E. Lesnik, S. Freier, Y. S. Sanghvi, K. Teng, A. Kawasaki, C. Guinosso, P. Wheeler, V. Mohan, and P. D. Cook. 1994. New Twists On Nucleic-Acids - Structural-Properties of Modified Nucleosides Incorporated Into Oligonucleotides, p. 212-224, Carbohydrate Modifications in Antisense Research, vol. 580.
1.Swartling, D., M. Fry, M. Morgan, E. Biehl, J. Balzarini, and E. Declercq. 1994. The Synthesis, Fluorescence and Antiviral Studies of 3'Amino- 2',3'-Dideoxythymidine Substituted 10-Cyano-9- Isothiocyanatoanthracene Adducts. Nucleosides & Nucleotides. 13(9):2013-2019.