back to publ. 1

59. Summerer D, Marx A: 4 ' C-ethynyl-thymidine acts as a chain terminator during DNA-synthesis catalyzed by HIV-1 reverse transcriptase. Bioorganic & Medicinal Chemistry Letters 2005, 15:869-871.

58. Moriyama K, Kimoto M, Mitsui T, Yokoyama S, Hirao I: Site-specific biotinylation of RNA molecules by transcription using unnatural base pairs. Nucleic Acids Research 2005, 33.

57. Misiura K, Szymanowicz D, Stec WJ: Synthesis of nucleoside alpha-thiotriphosphates via an oxathiaphospholane approach. Organic Letters 2005, 7:2217-2220.

56. Lai JS, Kool ET: Fluorous base-pairing effects in a DNA polymerase active site. Chemistry-a European Journal 2005, 11:2966-2971.

55. Kaufmann GF, Meijler MM, Sun CZ, Chen DW, Kujawa DP, Mee JM, Hoffman TZ, Wirsching P, Lerner RA, Janda KD: Enzymatic incorporation of an antibody-activated blue fluorophore into DNA. Angewandte Chemie-International Edition 2005, 44:2144-2148.

54. Ikeda Y, Kawahara SI, Yoshinari K, Fujita S, Taira K: Specific 3 '-terminal modification of DNA with a novel nucleoside analogue that allows a covalent linkage of a nuclear localization signal and enhancement of DNA stability. Chembiochem 2005, 6:297-303.

53. Zhang XM, Lee I, Berdis AJ: Evaluating the contributions of desolvation and base-stacking during translesion DNA synthesis. Organic & Biomolecular Chemistry 2004, 2:1703-1711.

52. Ozaki H, Kuwahara M, Sawai H: Synthesis and properties of oligonucleotides containing 5-substituted pyrimidine nucleoside. Journal of Synthetic Organic Chemistry Japan 2004, 62:1238-1248.

51. Marx A, Detmer I, Gaster J, Summerer D: Probing DNA polymerase function with synthetic nucleotides. Synthesis-Stuttgart 2004:1-14.

50. Kimoto M, Endo M, Mitsui T, Okuni T, Hirao I, Yokoyama S: Site-specific incorporation of a photo-crosslinking component into RNA by T7 transcription mediated by unnatural base pairs. Chemistry & Biology 2004, 11:47-55.

49. Hirao I, Harada Y, Kimoto M, Mitsui T, Fujiwara T, Yokoyama S: A two-unnatural-base-pair system toward the expansion of the genetic code. Journal of the American Chemical Society 2004, 126:13298-13305.

48. Henry AA, Olsen AG, Matsuda S, Yu CZ, Geierstanger BH, Romesberg FE: Efforts to expand the genetic alphabet: Identification of a replicable unnatural DNA self-pair. Journal of the American Chemical Society 2004, 126:6923-6931.

47. Endo M, Mitsui T, Okuni T, Kimoto A, Hirao I, Yokoyama S: Unnatural base pairs mediate the site-specific incorporation of an unnatural hydrophobic component into RNA transcripts. Bioorganic & Medicinal Chemistry Letters 2004, 14:2593-2596.

46. Wu WD, Bergstrom DE, Davisson VJ: A combination chemical and enzymatic approach for the preparation of azole carboxamide nucleoside triphosphate. Journal of Organic Chemistry 2003, 68:3860-3865.

45. Mitsui T, Kitamura A, Kimoto M, To T, Sato A, Hirao I, Yokoyama S: An unnatural hydrophobic base pair with shape complementarity between pyrrole-2-carbaldehyde and 9-methylimidazo (4,5)-b pyridine. Journal of the American Chemical Society 2003, 125:5298-5307.

44. Lang P, Gerez C, Tritsch D, Fontecave M, Biellmann JF, Burger A: Synthesis of 8-vinyladenosine 5 '-di- and 5 '-triphosphate: evaluation of the diphosphate compound on ribonucleotide reductase. Tetrahedron 2003, 59:7315-7322.

43. Kojima N, Inoue K, Nakajima-Shibata R, Kawahara S, Ohtsuka E: A new, but old, nucleoside analog: the first synthesis of 1-deaza-2 '-deoxyguanosine and its properties as a nucleoside and as oligodeoxynucleotides. Nucleic Acids Research 2003, 31:7175-7188.

42. Storek MJ, Ernst A, Verdine GL: High-resolution footprinting of sequence-specific protein-DNA contacts. Nature Biotechnology 2002, 20:183-186.

41. Storek MJ, Suciu A, Verdine GL: 5-amino-2 '-deoxyuridine, a novel thymidine analogue for high-resolution footprinting of protein-DNA complexes. Organic Letters 2002, 4:3867-3869.

40. Summerer D, Marx A: DNA polymerase selectivity: Sugar interactions monitored with high-fidelity nucleotides. Angewandte Chemie-International Edition 2001, 40:3693-+.

39. Matulic-Adamic J, Daniher AT, Karpeisky A, Haeberli P, Sweedler D, Beigelman L: Synthesis of modified nucleoside 5 '-triphosphates for in vitro selection of catalytic nucleic acids. Nucleosides Nucleotides & Nucleic Acids 2001, 20:1113-1115.

38. Lee SE, Sidorov A, Gourlain T, Mignet N, Thorpe SJ, Brazier JA, Dickman MJ, Hornby DP, Grasby JA, Williams DM: Enhancing the catalytic repertoire of nucleic acids: a systematic study of linker length and rigidity. Nucleic Acids Research 2001, 29:1565-1573.

37. Gourlain T, Sidorov A, Mignet N, Thorpe SJ, Lee SE, Grasby JA, Williams DM: Enhancing the catalytic repertoire of nucleic acids. II. Simultaneous incorporation of amino and imidazolyl functionalities by two modified triphosphates during PCR. Nucleic Acids Research 2001, 29:1898-1905.

36. Chen DW, Beuscher AE, Stevens RC, Wirsching P, Lerner RA, Janda KD: Preparation of stilbene-tethered nonnatural nucleosides for use with blue-fluorescent antibodies. Journal of Organic Chemistry 2001, 66:1725-1732.

35. Rao TVS, Haber MT, Sayer JM, Jerina DM: Incorporation of 4-thiothymidine into DNA by the klenow fragment and HIV-1 reverse transcriptase. Bioorganic & Medicinal Chemistry Letters 2000, 10:907-910.

34. Nampalli S, Kumar S: Efficient synthesis of 8-oxo-dGTP: A mutagenic nucleotide. Bioorganic & Medicinal Chemistry Letters 2000, 10:1677-1679.

33. Matulic-Adamic J, Daniher AT, Karpeisky A, Haeberli P, Sweedler D, Beigelman L: Functionalized nucleoside 5 '-triphosphates for in vitro selection of new catalytic ribonucleic acids. Bioorganic & Medicinal Chemistry Letters 2000, 10:1299-1302.

32. Burgess K, Cook D: Syntheses of nucleoside triphosphates. Chemical Reviews 2000, 100:2047-2059.

31. Berger M, Wu YQ, Ogawa AK, McMinn DL, Schultz PG, Romesberg FE: Universal bases for hybridization, replication and chain termination. Nucleic Acids Research 2000, 28:2911-2914.

30. Aoki S, Kimura E: Highly selective recognition of thymidine mono- and diphosphate nucleotides in aqueous solution by ditopic receptors zinc(II)-bis(cyclen) complexes (cyclen 1,4,7,10-tetraazacyclododecane). Journal of the American Chemical Society 2000, 122:4542-4548.

29. Manfredini S, Baraldi PG, Durini E, Balzarini J, De Clercq E, Karlsson A, Buzzoni V, Thelander L: Synthesis, cytostatic activity and inhibition of ribonucleotide reductase by 5 '-phosphoramidates and 5 '-diphosphates, of 2 '-O-allyl-arabinofuranosyl nucleosides. Nucleosides & Nucleotides 1999, 18:1007-1008.

28. Manfredini S, Baraldi PG, Durini E, Vertuani S, Balzarini J, De Clercq E, Karlsson A, Buzzoni V, Thelander L: 5 '-phosphoramidates and 5 '-diphosphates of 2 '-O-allyl-beta-D-arabinofuranosyluracil, -cytosine, and -adenine: Inhibition of ribonucleotide reductase. Journal of Medicinal Chemistry 1999, 42:3243-3250.

27. Knoblauch BHA, Muller CE, Jarlebark L, Lawoko G, Kottke T, Wikstrom MA, Heilbronn E: 5-substituted UTP derivatives as P2Y(2) receptor agonists. European Journal of Medicinal Chemistry 1999, 34:809-824.

26. Fischer B, Yefidoff R, Major DT, Rutman-Halili I, Shneyvays V, Zinman T, Jacobson KA, Shainberg A: Characterization of "mini-nucleotides" as P2X receptor agonists in rat cardiomyocyte cultures. An integrated synthetic, biochemical, and theoretical study. Journal of Medicinal Chemistry 1999, 42:2685-2696.

25. Sakthivel K, Barbas CF: Expanding the potential of DNA for binding and catalysis: Highly functionalized dUTP derivatives that are substrates for thermostable DNA polymerases. Angewandte Chemie-International Edition 1998, 37:2872-2875.

24. Moran S, Ren RXF, Kool ET: A thymidine triphosphate shape analog lacking Watson-Crick pairing ability is replicated with high sequence selectivity. Proceedings of the National Academy of Sciences of the United States of America 1997, 94:10506-10511.

23. Marx A, MacWilliams MP, Bickle TA, Schwitter U, Giese B: 4'-acylated thymidines: A new class of DNA chain terminators and photocleavable DNA building blocks. Journal of the American Chemical Society 1997, 119:1131-1132.

22. Jacutin S, Zhang AJ, Russell DH, Gibbs RA, Burgess K: Test of the potential of a dATP surrogate for sequencing via MALDI-MS. Nucleic Acids Research 1997, 25:5072-5076.

21. Gopal D, Pavlov DI, Levitsky DI, Ikebe M, Burke M: Chemomechanical transduction in the actomyosin molecular motor by 2',3'-dideoxydidehvdro-ATP and characterization of its interaction with myosin subfragment 1 in the presence and absence of actin. Biochemistry 1996, 35:10149-10157.

20. Porter KW, Tomasz J, Huang FQ, Sood A, Shaw BR: N-7-Cyanoborane-2'-Deoxyguanosine 5'-Triphosphate Is a Good Substrate for DNA-Polymerase. Biochemistry 1995, 34:11963-11969.

19. Pongracz K, Dosanjh MK, Singer B, Bodell WJ: Synthesis of a 25 Base Oligonucleotide Containing a Styrene Oxide Modification at the O-6 Position of 2'-Deoxyguanosine at a Defined Site and Incorporation Studies of the Similarly Modified 2'-Deoxyguanosine-5'-Triphosphate. Carcinogenesis 1994, 15:1371-1375.

18. Herrlein MK, Konrad RE, Engels JW, Holletz T, Cech D: 3'-Amino-Modified Nucleotides Useful as Potent Chain Terminators for Current DNA-Sequencing Methods. Helvetica Chimica Acta 1994, 77:586-596.

17. Burnstock G, Fischer B, Hoyle CHV, Maillard M, Ziganshin AU, Brizzolara AL, Vonisakovics A, Boyer JL, Harden TK, Jacobson KA: Structure-Activity-Relationships for Derivatives of Adenosine-5'-Triphosphate as Agonists at P-2 Purinoceptors - Heterogeneity within P-2x and P-2y Subtypes. Drug Development Research 1994, 31:206-219.

16. Zimmet J, Jarlebark L, Hammarberg T, Vangalen PJM, Jacobson KA, Heilbronn E: Synthesis and Biological-Activity of Novel 2-Thio Derivatives of Atp. Nucleosides & Nucleotides 1993, 12:1-20.

15. Johns DG, Ahluwalia GS, Cooney DA, Mitsuya H, Driscoll JS: Enhanced Stimulation by Ribavirin of the 5'-Phosphorylation and Anti-Human-Immunodeficiency-Virus Activity of Purine 2'-Beta-Fluoro-2',3'-Dideoxynucleosides. Molecular Pharmacology 1993, 44:519-523.

14. Fischer B, Boyer JL, Hoyle CHV, Ziganshin AU, Brizzolara AL, Knight GE, Zimmet J, Burnstock G, Harden TK, Jacobson KA: Identification of Potent, Selective P-2y-Purinoceptor Agonists - Structure-Activity-Relationships for 2-Thioether Derivatives of Adenosine 5'-Triphosphate. Journal of Medicinal Chemistry 1993, 36:3937-3946.

13. Vandraanen NA, Tucker SC, Boyd FL, Trotter BW, Reardon JE: Beta-L-Thymidine 5'-Triphosphate Analogs as DNA-Polymerase Substrates. Journal of Biological Chemistry 1992, 267:25019-25024.

12. Seela F, Gumbiowski R: Imidazo 1,2-a Pyrimidine 2'-Deoxyribonucleoside and 2',3'-Dideoxyribonucleoside - Glycosylation of the Nucleobase Anion. Liebigs Annalen Der Chemie 1992:679-686.

11. Miller WH, Daluge SM, Garvey EP, Hopkins S, Reardon JE, Boyd FL, Miller RL: Phosphorylation of Carbovir Enantiomers by Cellular Enzymes Determines the Stereoselectivity of Antiviral Activity. Journal of Biological Chemistry 1992, 267:21220-21224.

10. Krecmerova M, Seela F: 9-(2-Deoxy-Beta-D-Xylofuranosyl)Adenine and 1-(2-Deoxy-Beta-D-Xylofuranosyl)Thymine - Phosphorylation and Stability. Nucleosides & Nucleotides 1992, 11:1393-1409.

9. Seela F, Muth HP, Roling A: Syntheses of Pyrrolo 2,3-D Pyrimidine 2',3'-Dideoxyribonucleosides Related to 2',3'-Dideoxyadenosine and 2',3'-Dideoxyguanosine and Inhibitory Activity of 5'-Triphosphates on Hiv-1 Reverse-Transcriptase. Helvetica Chimica Acta 1991, 74:554-564.

8. Mishra NC, Broom AD: A Novel Synthesis of Nucleoside 5'-Triphosphates. Journal of the Chemical Society-Chemical Communications 1991:1276-1277.

7. Zhu Z, Schinazi RF, Chu CK, Williams GJ, Colby CB, Sommadossi JP: Cellular-Metabolism of 3'-Azido-2',3'-Dideoxyuridine with Formation of 5'-O-Diphosphohexose Derivatives by Previously Unrecognized Metabolic Pathways for 2'-Deoxyuridine Analogs. Molecular Pharmacology 1990, 38:929-938.

6. Vonjantalipinski M, Matthes E, Gaertner K, Schildt J, Langen P: Fluorosugar Nucleosides - the Synthesis of Analogs of 2',3'-Dideoxy-3'-Fluoro-Uridine and the Corresponding 5'-O-Triphosphates. Zeitschrift Fur Chemie 1990, 30:171-172.

5. Masood R, Ahluwalia GS, Cooney DA, Fridland A, Marquez VE, Driscoll JS, Zhang H, Mitsuya H, Perno CF, Broder S, et al.: 2'-Fluoro-2',3'-Dideoxyarabinosyladenine - a Metabolically Stable Analog of the Antiretroviral Agent 2',3'-Dideoxyadenosine. Molecular Pharmacology 1990, 37:590-596.

4. Kedar PS, Abbotts J, Kovacs T, Lesiak K, Torrence P, Wilson SH: Mechanism of Hiv Reverse-Transcriptase - Enzyme Primer Interaction as Revealed through Studies of a Dntp Analog, 3'-Azido-Dttp. Biochemistry 1990, 29:3603-3611.

3. Fridland A, Johnson MA, Cooney DA, Ahluwalia G, Marquez VE, Driscoll JS, Johns DG: Metabolism in Human-Leukocytes of Anti-Hiv Dideoxypurine Nucleosides. Annals of the New York Academy of Sciences 1990, 616:205-216.

2. Folkman W, Kusmierek JT, Singer B: A New One-Step Method for the Preparation of 3',5'-Bisphosphates of Acid-Labile Deoxynucleosides. Chemical Research in Toxicology 1990, 3:536-539.

1. Coe D, Flitsch SL, Hilpert H, Liebster M, Roberts SM, Turner NJ: An Improved Method for the Synthesis of Highly Substituted Alkyl Phosphates Including Nucleoside 5-'-Phosphates. Chemistry & Industry 1989:724-725.